SI4802B: K48-Linked Biotinylated Di-Ubiquitin

SKU SI-4802-B100 Categories Biotinylated Ubiquitin Chains, Ubiquitin Chains, Ubiquitin Chains and Derivatives

LifeSensors’ SI4802B is a K48-linked biotinylated di-ubiquitin used for studying poly-ubiquitylation and DUB linkage specificity in protein research. Ideal for biochemical assays.

$363.00

In stock

Poly-ubiquitylation of target proteins through linkage at K48, is now the most thoroughly studied of the various chain linkages, and we once considered the hallmark of this post-translational modification. It is now clear that many, if not all, poly-Ub chain topologies likely play distinct and important roles in regulating cellular processes. Nevertheless, the K48 linkage remains a critical pathway for cells to maintain homeostasis through proteolytic degradation, and as such remains very intriguing for the study of DUBs that play a role in the degradation, as well as the proteasome itself. These di-ubiquitin chains generated from the enzymatic linkage of wild-type ubiquitin through lysine 48. The most distal ubiquitin contains an arginine substitution for the lysine at position 48, limiting chain length.

Info

Species	Human
Source	E. coli
Tag	None
Molecular Weight	17,139.7 Da
Quantity	100µg
Concentration	Variable
Formulation	Phosphate Buffered Saline pH 7.4
Storage	-80°C, avoid freeze/thaw cycles

Datasheet

Investigation of DUB linkage specificity

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All orders placed within The United States are subject to a flat shipping fee of $80. Orders are shipped via FedEx Express Standard Overnight.

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All orders placed within Canada are subject to a flat shipping rate of $185. Orders are shipped via FedEx Express International Priority. Shipments to Canada will only be sent from our facility on Monday, Tuesday, and Wednesday to allow for adequate delivery time.

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All orders to be delivered to Europe, Asia, Australia and South America are subject to a flat shipping fee of $325. Orders are shipped via FedEx Express International Priority.

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SI4802B: K48-Linked Biotinylated Di-Ubiquitin

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