SI0102P: M1 (linear) Di-Ubiquitin (Phosphorylated)

LifeSensors’ SI0102P is a phosphorylated M1 (linear) Di-Ubiquitin, designed for advanced research on ubiquitin signaling, protein degradation, and cellular regulation

$595.00

M1-linked ubiquitination is traditionally associated with regulation of NFĸB and IFN signaling. Phospho-ubiquitin chains represent a specialized class of polyubiquitin characterized by phosphorylation at Serine 65 and play a central role in mitophagy signaling pathways. M1 Di-Ubiquitin (phosphorylated) is a dimeric chain of wild-type ubiquitin. It is expressed as a linear chain wherein monomers are linked through N-terminal methionines and C-terminal glycines. The chains are then enzymatically phosphorylated at the Ser65 position. Info

Species	Human
Source	E. coli
Tag	None
Molecular Weight	17866-17946 Da (depending on degree of phosphorylation)
Quantity	25µg
Concentration	Variable
Formulation	20 mM Tris pH 7.5, 150 mM NaCl
Storage	-80°C, avoid freeze/thaw cycles

Datasheet

Investigation of phospho-ubiquitin chain specificity and selectivity
Studies on the role of phospho-ubiquitin chains in protein degradation pathways (e.g., proteasomal and autophagic degradation)
Analysis of phospho-ubiquitin-mediated signaling pathways and cellular responses
Structural studies to elucidate the architecture and dynamics of phospho-ubiquitin chains
Screening assays to identify modulators of phospho-ubiquitin chain assembly and disassembly processes

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All orders placed within The United States are subject to a flat shipping fee of $80. Orders are shipped via FedEx Express Standard Overnight.

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All orders placed within Canada are subject to a flat shipping rate of $185. Orders are shipped via FedEx Express International Priority. Shipments to Canada will only be sent from our facility on Monday, Tuesday, and Wednesday to allow for adequate delivery time.

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All orders to be delivered to Europe, Asia, Australia and South America are subject to a flat shipping fee of $325. Orders are shipped via FedEx Express International Priority.

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SI0102P: M1 (linear) Di-Ubiquitin (Phosphorylated)

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