Questions about a product, technology or experimental design? Give us a call 610-644-8845
Questions about a product, technology or experimental design? Give us a call 610-644-8845.

PC1003: VH298

SKU PC-1003 Categories ,
LifeSensors’ PC1003: VH298 is a high-quality PROTAC tool compound designed for targeted protein degradation research and drug discovery applications

Price range: $134.00 through $608.00

VH298 is a cell permeable high-affinity inhibitor of E3 ubiquitin ligase VHL (Kd = 80-90 nM). It blocks interaction between VHL and HIF-α downstream of HIF-α hydroxylation, initiating a hypoxic response. Results in time- and concentration-dependent accumulation of hydroxylated HIF-α, and upregulates mRNA and protein levels of HIF target genes.

Info

Purity >98%
Quantity 5mg, 10mg, 25mg
Molecular Weight 523.65 g/mol
Physical State Lyophilized white powder
Solubility 50 mg/mL in DMSO; 50 mg/mL in Ethanol
CAS No. 2097381-85-4
Storage solutions at -20°C or -80°C; desiccated at -20°C, avoid freeze/thaw cycles

VH298 is a high-affinity inhibitor of VHL

Domestic Delivery
All orders placed within The United States are subject to a flat shipping fee of $80. Orders are shipped via FedEx Express Standard Overnight.

International Shipping to Canada
All orders placed within Canada are subject to a flat shipping rate of $185. Orders are shipped via FedEx Express International Priority. Shipments to Canada will only be sent from our facility on Monday, Tuesday, and Wednesday to allow for adequate delivery time.

International Worldwide
All orders to be delivered to Europe, Asia, Australia and South America are subject to a flat shipping fee of $325. Orders are shipped via FedEx Express International Priority.

Customers can also use their own shipping account for deliveries if preferred. Please include the Fedex or DHL shipping account number when the order is placed or reach out to customerservice@lifesensors.com for more information.

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PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

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