Specifications
VH298 is a cell permeable high-affinity inhibitor of E3 ubiquitin ligase VHL (Kd = 80-90 nM). It blocks interaction between VHL and HIF-α downstream of HIF-α hydroxylation, initiating a hypoxic response. Results in time- and concentration-dependent accumulation of hydroxylated HIF-α, and upregulates mRNA and protein levels of HIF target genes.
Info
| Purity | >98% |
| Quantity | 5 mg, 10 mg, 25 mg |
| Molecular Weight | 523.65 g/mol |
| Physical State | Lyophilized white powder |
| Solubility | 50 mg/mL in DMSO; 50 mg/mL in Ethanol |
| CAS No. | 2097381-85-4 |
| Storage | solutions at -20°C or -80°C; desiccated at -20°C, avoid freeze/thaw cycles |
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