Questions about a product, technology or experimental design? Give us a call 610-644-8845
Questions about a product, technology or experimental design? Give us a call 610-644-8845.

PC1001: MZ1

SKU PC-1001 Categories ,
LifeSensors’ PC1001 (MZ1) is a cell-penetrant PROTAC compound combining (+)-JQ1 with a VHL ligand for targeted protein degradation in research applications

Price range: $341.00 through $464.00

MZ1 is a cell penetrant PROteolysis TArgeting Chimera (PROTAC) compound based on (+)-JQ1 conjugated to a von Hippel-Lindau (VHL) ligand. It retains high affinity for BRD2, BRD3 and BRD4 bromodomains (Kd = 13-60 nM) but induces preferential degradation of BRD4 over BRD2 and BRD3. (DC50 values for degradation of BRD4 are 8 and 23 nM in H661 and H838 cells, respectively). MZ1 exhibits potent cytotoxicity and anti-proliferative effects in AML cell lines (pEC50 = 7.6 in Mv4-11 cells).

Info

Purity >98.0%
Quantity 1mg, 5mg
Molecular Weight 1002.64 g/mol
Physical State Lyophilized white to off-white solid
Solubility 100 mg/mL in DMSO; 100 mg/ml in ethanol
CAS No. 1797406-69-9
Storage solutions at -80°C; desiccated at -20°C, avoid freeze/thaw cycles

MZ1 is a JQ1 based PROTAC that selectively degrades BRD4 in cells

Domestic Delivery
All orders placed within The United States are subject to a flat shipping fee of $80. Orders are shipped via FedEx Express Standard Overnight.

International Shipping to Canada
All orders placed within Canada are subject to a flat shipping rate of $185. Orders are shipped via FedEx Express International Priority. Shipments to Canada will only be sent from our facility on Monday, Tuesday, and Wednesday to allow for adequate delivery time.

International Worldwide
All orders to be delivered to Europe, Asia, Australia and South America are subject to a flat shipping fee of $325. Orders are shipped via FedEx Express International Priority.

Customers can also use their own shipping account for deliveries if preferred. Please include the Fedex or DHL shipping account number when the order is placed or reach out to customerservice@lifesensors.com for more information.

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PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

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