Extracellular Targeted Protein Degradation (eTPD)

Advancing protein degradation beyond traditional boundaries with innovative extracellular targeting strategies

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eTPD is a distinct mode of targeted degradation of extracellular proteins. eTPD utilizes bi-specific antibodies or small molecules that recruit membrane-bound or secreted target proteins to specific membrane-associated cycling receptors, transporting the cargo to lysosomes for degradation.

Key Differentiator

Unlike PROTACs, eTPD is not limited by the choice of E3 ligase ligands and can employ multiple degradation systems, offering better tissue selectivity. Kinetics of degradation using eTPD modality may be slower compared to traditional PROTACs.

Explore the diverse approaches to extracellular targeted protein degradation:

Utilizing antibodies to target and clear soluble proteins of interest through receptor-mediated endocytosis.

Leveraging glycan recognition for targeted degradation through circulatory receptor pathways.

Employing transmembrane E3 ligases to degrade membrane-associated target proteins.

Using cytokine-receptor interactions to facilitate membrane protein degradation.

Harnessing integrin pathways for selective protein degradation at the cell surface.

Simultaneous Studies

Study PROTAC-mediated Ubiquitination and Degradation simultaneously for comprehensive insights

Complete Validation Suite

Complete suite of validation studies to establish binding, ternary complex formation, and cellular degradation

Novel E3 Ligases

Experience with novel E3 ligases – ~30 E3 ligases amenable to PROTAC discovery

Proteomics Expertise

Proteomics to characterize protein degradation – establish selectivity with precision

With deep and diverse expertise in medicinal chemistry, biochemistry, and cell biology specializing in ubiquitin-based drug discovery for the last 17 years, LifeSensors is proud to offer efficient methods to accelerate your discovery of novel molecules facilitating targeted protein degradation.

Comprehensive Service Portfolio

We offer our degrader discovery services starting from design and synthesis of novel PROTACs, to monitoring PROTAC binding to target and E3 ligases (biochemical and biophysical), including functional ubiquitination and degradation assays in cells.

Your biochemists can focus on new PROTAC targets as LifeSensors will translate its core technologies for in vitro and cellular PROTAC screens.