Questions about a product, technology or experimental design? Give us a call 610-644-8845
Questions about a product, technology or experimental design? Give us a call 610-644-8845.
Current Paradigms and Innovative Research
Dear Colleagues,
Alzheimer’s and Parkinson’s diseases are the silent killers. Despite a massive investment, the failure rate in drug development is 99.6%. The largest hurdle in developing a radical therapy for Alzheimer’s disease (AD) and Parkinson’s Disease (PD) is a lack of a simple diagnostic blood test. Current diagnostics are expensive, unreliable, and cumbersome brain imaging systems to scan b-amyloid plaques or tau fibers. There is a better way. A simple blood based biomarker will pave the way to radical and effective AD and PD treatment.
The Ubiquitin Proteasome System (UPS) is responsible for cleaning misfolded or damaged proteins in cells. The UPS can be likened to the quality control and protein trafficking system of the cell. If the UPS is defective, cell pathways are clogged, and protein aggregates accumulate. A dysfunctional UPS marked by changes in the pattern of ubiquitylated proteins is likely the root cause of neurodegenerative diseases such as AD and PD.
This failure in the UPS can be leveraged to diagnose AD and PD much earlier than previously thought possible. The signatures of AD and PD associated with a dysfunctional UPS manifest long before outward symptoms of the disease become evident. By following these signatures in the blood, we can proactively diagnose neurodegenerative diseases early, as well as monitor the course of AD and PD as it progresses.
LifeSensors believes educating the general public about UPS is key to helping researchers gain the support they require. To support this initiative, LifeSensors has published a recent blog post, Ubiquitin: Hope for the Future of Alzheimer’s Research. It is our hope that these resources will be useful in laying a foundation of common understanding, which will in turn lead to increased support towards the future of AD and PD research.
LifeSensors Inc.
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With ubiquitin’s core functions in plants and animals being so similar it has long been speculated that insights into the
The functional consequences of protein polyubiquitination are determined by the type of ubiquitin chain assembled on the substrate. Among the
While direct K-RAS inhibitors represent a major therapeutic advance, targeting this oncoprotein remains a significant challenge due to limited druggable
Pan-selective Tandem Ubiquitin-Binding Entities (TUBEs) are engineered, high-affinity reagents composed of multiple ubiquitin-associated (UBA) domains that bind polyubiquitin chains with
LifeSensors is pleased to bring attention to some of our academic colleagues who have used our products in the past
Different lysines on ubiquitin are involved in forming different ubiquitin chains, with K48-linked chains primarily signaling for proteasomal degradation, while
With ubiquitin’s core functions in plants and animals being so similar it has long been speculated that insights into the
The functional consequences of protein polyubiquitination are determined by the type of ubiquitin chain assembled on the substrate. Among the
While direct K-RAS inhibitors represent a major therapeutic advance, targeting this oncoprotein remains a significant challenge due to limited druggable
Pan-selective Tandem Ubiquitin-Binding Entities (TUBEs) are engineered, high-affinity reagents composed of multiple ubiquitin-associated (UBA) domains that bind polyubiquitin chains with
LifeSensors is pleased to bring attention to some of our academic colleagues who have used our products in the past
Different lysines on ubiquitin are involved in forming different ubiquitin chains, with K48-linked chains primarily signaling for proteasomal degradation, while
