By: Derrick Padykula and Isabelle Wentzel Hallmark of Neurodegeneration Diving into the complex world of neurodegeneration unveils the long road marked by the gradual decline of neuronal cells, ultimately leading to cell death. In Parkinson’s disease (PD) and Alzheimer’s disease (AD), the accumulation of aggregated proteins and dysfunctional mitochondria is what contributes to the demise of […]
[Malvern, PA, October 18, 2023] — LifeSensors Inc., a biotech company targeting the ubiquitin proteasome system for drug discovery and diagnostic markers, has received funding from the National Institute on Aging and National Institute of General Medicine. The funding, to the tune of $5.53 million, provides for the development of PROTAC drug discovery technologies. PROTACs […]
Lewy Body Dementia (LBD) is a debilitating neurodegenerative disease that is increasingly becoming a public health concern. “In Lewy body dementia, alpha-synuclein forms into clumps inside neurons, starting in areas of the brain that control aspects of memory and movement. This process causes neurons to work less effectively and, eventually, to die.” Currently, 1 in […]
ABSTRACT Ubiquitin-Proteasome system (UPS), along with chaperone mediated-autophagy (CMA) and macroautophagy, constitutes the protein quality control system of the cell. The failure of these systems is particularly difficult to overcome in the cells that rarely grow and divide, e.g. neurons. We believe that dysfunction in UPS dysfunction plays a key causative role in diseases such […]
By: Mark Tingey, Katelyn Roberts, and Meredith Paterson Parkinson’s disease is often referred to as a silent disease. It often begins in very innocuous ways, small ticks and behaviors that are almost imperceptible. This is how it began with Alan Alda. In a recent interview, he explained that he first suspected something was amiss when […]
PROTEIN PROFILES MARK TINGEY, DOMINIC VASTURIA, AND KATIE SHEETS Next in its series of educational posts, LifeSensors is proud to discuss the role the proteins play in neurodegenerative diseases. This series of posts will inform as to the general nature of proteins and what proteins have been implicated in the neurodegenerative diseases Alzheimer’s Disease and […]
UBIQUITIN: HOPE FOR THE FUTURE OF ALZHEIMER’S RESEARCH by: Mark Tingey and Peter Foote Uncle Walt stared at us, not recognizing us or remembering our names. His eyes, which were once bright and filled with curiosity, were now fearful and withdrawn. He appeared to crumple in upon himself, as if the world he no longer […]
