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SI217: Ubiquitin-K48R

LifeSensors SI217 is a tag-free recombinant human ubiquitin with a K48R mutation, preventing lysine 48-linked polyubiquitin chain formation, ideal for structural and linkage studies.

$184.00

SKU SI-0217-1000 Categories Ubiquitin Chains, Ubiquitin Chains and Derivatives, Ubiquitin K to R mutants

In stock

Product Advantages

Applications

Investigation of E1-E2-E3 mediated ubiquitin ligation.

Investigation of DUB linkage specificity.

Recombinant ubiquitin having a single substitution of arginine for lysine at position 48. Ubiquitin is a small polypeptide that can be conjugated via its C-terminus to amine groups of lysine residue on target proteins. This conjunction is referred to as monoubiquitylation. Additional ubiquitin moieties can subsequently conjugated to this initial ubiquitin, utilizing any one (of seven) lysine residues on the surface of ubiquitin. The formation of these ubiquitin chains is referred to as polyubiquitylation.

Info

Species	Human
Source	E. coli
Tag	None
Molecular Weight	8,592 Da
Quantity	1 mg
Concentration	Variable
Formulation	PBS with 10% glycerol
Storage	-80°C, avoid freeze/thaw cycles

Datasheet

Datasheet

Applications

Investigation of E1-E2-E3 mediated ubiquitin ligation.

Investigation of DUB linkage specificity.

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