SI208: Ubiquitin-K63

SKU SI-0208-1000 Categories Ubiquitin Chains, Ubiquitin Chains and Derivatives

LifeSensors’ SI208 is a high-purity human recombinant ubiquitin K63, produced in E. coli, used for studying protein ubiquitination and signaling pathways in biomedical research

$187.00

In stock

Ubiquitin is a small polypeptide that can be conjugated via its C-terminus to amine groups of lysine residue on target proteins. This conjunction is referred to as monoubiquitylation. Additional ubiquitin moieties can be subsequently conjugated to this initial ubiquitin, utilizing any one (of seven) lysine residues on the surface of ubiquitin. The formation of these ubiquitin chains is referred to as polyubiquitylation. This tag-free recombinant form of human ubiquitin is engineered to have all available lysines mutated to arginines, except at position 63. This molecule, therefore, can only form polyubiquitin chains of K63 linkage type.

Info

Species	Human
Source	E. coli
Tag	None
Molecular Weight	8,732 Da
Quantity	1mg
Concentration	Variable
Formulation	20 mM Tris pH 7.5, 150 mM NaCl, 10% glycerol
Storage	-80°C, avoid freeze/thaw cycles

Datasheet

Characterization of proteins responsible for ubiquitin conjugation or removal
Ligand binding studies with ubiquitin related proteins

Characterization of linkage type for target protein

Profiling of E2/E3 interactions

Characterization of E3 polyubiquitylation activity

Native (tag free) recombinant wild-type ubiquitin

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SI208: Ubiquitin-K63

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