SI6303: K63-Linked Tri-Ubiquitin

SKU SI-6303-0100 Categories Ubiquitin Chains, Ubiquitin Chains and Derivatives

LifeSensors’ SI6303 is a human K63-linked tri-ubiquitin protein used in biochemical research, expressed in E. coli, with a molecular weight of ~25.7 kDa and supplied at 100µg

$414.00

In stock

Polyubiquitination of target proteins through K63 has recently become the focus of intense study. The topology of this linkage type is quite different from polyubiquitin linked through lysine 48. Modification of proteins by K63-linked polyubiquitination has been implicated in, among other cellular processes, the regulation of the DNA damage response, endosomal sorting, autophagy of misfolded/aggregated proteins, neurodegeneration, and signal transduction. These tri-ubiquitin chains are generated from the enzymatic linkage of wild-type ubiquitin through lysine 63. The most distal ubiquitin contains an arginine substitution for the lysine at position 63, limiting chain length.

Info

Species	Human
Source	E. coli
Tag	None
Molecular Weight	25,686.5 Da
Quantity	100µg
Concentration	Variable
Formulation	20 mM Tris pH 7.5, 150 mM NaCl, 1 mM EDTA
Storage	-80°C, avoid freeze/thaw cycles

Datasheet

Domestic Delivery
All orders placed within The United States are subject to a flat shipping fee of $80. Orders are shipped via FedEx Express Standard Overnight.

International Shipping to Canada
All orders placed within Canada are subject to a flat shipping rate of $185. Orders are shipped via FedEx Express International Priority. Shipments to Canada will only be sent from our facility on Monday, Tuesday, and Wednesday to allow for adequate delivery time.

International Worldwide
All orders to be delivered to Europe, Asia, Australia and South America are subject to a flat shipping fee of $325. Orders are shipped via FedEx Express International Priority.

Customers can also use their own shipping account for deliveries if preferred. Please include the Fedex or DHL shipping account number when the order is placed or reach out to customerservice@lifesensors.com for more information.

Phone (Office)

610.644.8845

Available Monday – Friday, 9:00 AM – 5:00 PM EST

Send Email

info@lifesensors.com

We typically respond within 24 hours

Visit Anytime

271 Great Valley Parkway Malvern, PA 19355

Send us a Message

Have a question about our solutions? We’d love to hear from you.

First Name *

Last Name *

Email Address *

Phone Number

Company/Organization

Subject*

Message *

I would like to receive updates about new products and research developments

* Required fields

SI6303: K63-Linked Tri-Ubiquitin

Info

Follow Us

Send us a Message

More from This Category

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

Custom Solutions

Learning Center