SI6302: K63-Linked Di-Ubiquitin

LifeSensors SI6302 is a K63-linked di-ubiquitin protein used in biochemical research to study ubiquitination pathways and protein regulation. Available in phosphorylated forms.

$249.00

SKU SI-6302-0050 Categories Ubiquitin Chains, Ubiquitin Chains and Derivatives

In stock

Product Advantages

Applications

Investigation of DUB linkage specificity.

Poly-ubiquitination of target proteins through K63 has recently become the focus of intense study. The topology of this linkage type is quite different from polyubiquitin linked through lysine 48. Modification of proteins by K63-linked poly-ubiquitination has been implicated in, among other cellular processes, the regulation of the DNA damage response, endosomal sorting, autophagy of misfolded/aggregated proteins, and neurodegeneration. These K63 di-ubiquitin chains are generated from the enzymatic linkage of wild-type ubiquitin through lysine 63. The most distal ubiquitin contains an arginine substitution for the lysine at position 63, limiting chain length.

Info

Species	Human
Source	E. coli
Tag	None
Molecular Weight	17,139.7 Da
Quantity	50 µg
Concentration	Variable
Formulation	20 mM Tris, pH 7.5, 150 mM NaCl, 1 mM EDTA
Storage	-80°C, avoid freeze/thaw cycles