SI4804F: K48-Tetra-Ubiquitin Fluorescein-Labeled

SKU SI-4804-F025 Categories Ubiquitin Chains, Ubiquitin Chains and Derivatives

LifeSensors’ SI4804F is a fluorescein-labeled K48-linked tetra-ubiquitin used for studying poly-ubiquitylation at K48 linkage, a key process in protein regulation

$456.00

In stock

Poly-ubiquitylation of target proteins through linkage at K48 is the most thoroughly studied of the various ubiquitin chain linkages. It is now clear that many, if not all, poly-Ub chain topologies are likely to play distinct and important roles in regulating cellular processes. Nevertheless, K48 linkages remain a critical pathway for cells to maintain protein homeostasis and remain intriguing for the study of DUBs that play a role in regulating degradation, as well as the proteasome itself. These tetra-ubiquitin chains are generated by the enzymatic linkage of wild-type ubiquitin through lysine 48. The most distal ubiquitin contains a Lys48 to Arg substitution limiting chain length. The fluorescein moiety is attached to a single, non-lysine site in the proximal ubiquitin.

Info

Species	Human
Source	E. coli
Tag	None
Molecular Weight	34,678.3 Da
Quantity	25µg
Concentration	Variable
Formulation
Storage	-80°C, avoid freeze/thaw cycles

Datasheet

Optimization of pull-down conditions for anti-K48 TUBE and anti K63-TUBE reagents

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SI4804F: K48-Tetra-Ubiquitin Fluorescein-Labeled

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