DB505: USP14

Lifesensors DB505 is a specialized assay tool designed for precise ubiquitin-proteasome research, enabling advanced protein regulation and interaction studies.

$152.00

SKU DB-0505-0025 Categories DUBs, Neurodegeneration Tools, Neuronal DUBs and Ligases, Ubiquitin and Neuro-degeneration, USP Family of DUBs Tags Deubiquitinating enzyme, DUB

In stock

Product Advantages

Applications

This enzyme cleaves K48-linked ubiquitin chains in vitro.

USP14 (Ubiquitin Specific Protease 14) is a proteasome-associated deubiquitinase which releases ubiquitin from the proteasome-targeted ubiquitinated proteins. This enzyme serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded ER proteins via interaction with ERN1. It also plays a role in the innate immune defense against viruses by stabilizing the viral DNA sensor CGAS and thus inhibiting its autophagic degradation.

Info

Species	Human
Source	E. coli
Tag	His₆+ SUMO
Molecular Weight	68 kDa
Quantity	25 µg
Concentration	Variable
Formulation
Storage	-80°C, avoid freeze/thaw cycles