Tragedy to Transformation – Molecular Glue Sparks the Field of Targeted Protein Degradation

By: Isabelle Wentzel Devastating Origins In the late 1950s and early 1960s, pregnant women who experienced nausea and morning sickness were prescribed thalidomide, a sedative drug meant to treat these symptoms. In early 1960, it quickly became evident that there was a link between the thousands of infants born with severe birth defects and […]
Drug Discovery with UbiTest Technology

UbiTest: Detection of polyubiquitinated proteins using TUBE based screening platforms by Gauthami S. Jalagadugula The ubiquitin proteasome system (UPS) is a highly regulated mechanism that controls many cellular processes through protein ubiquitination and degradation. Ubiquitin is conjugated via its C-terminus to lysine residues on the target proteins as a monomer or as a polymer chain. […]