Establishing Ubiquitylation Patterns in Cells: Efficient Monitoring of Oncogenic Ubiquitylation Activity

Lifesensors recently presented the work of Peter Foote, Xialong Lu, Apurva Chaturvedi, and Rajesh Singh at AACR2018. A PDF of this poster can be downloaded here. ABSTRACT Ubiquitylation is a versatile post-translational modification involved in nearly all biological functions in eukaryotes. Ubiquitylation is catalyzed by three enzymes: ubiquitin activating enzyme (E1), ubiquitin conjugating enzyme (E2) and ubiquitin ligase […]
Ubiquitin code: Accelerating the discovery of poly-ubiquitylated proteins by novel chain-selective affinity matrices

LifeSensors’ Scientists Apurva Chaturvedi, Peter Foote, Dominic Vasturia, and Rajesh Singh recently presented their research at AACR2018. A pdf of this poster can be downloaded here. ABSTRACT Purpose of study: The work presented here focuses on developing easy to use tools to distinguish between specific ubiquitin chain linkages, which are involved in a multitude of cellular functions. […]