SI0602P: K6-Linked Di-Ubiquitin (Phosphorylated)

SKU SI-0602P-0025 Categories All, Phosphorylated Ubiquitin Chains, Ubiquitin and Neuro-degeneration, Ubiquitin Chains, Ubiquitin Chains and Derivatives, Ubiquitin Derivatives

LifeSensors’ SI0602P is a phosphorylated K6-linked Di-Ubiquitin, key in mitophagy and DNA damage response research, enabling advanced studies in ubiquitin signaling

$695.00

K6-linked ubiquitination is traditionally associated with mitophagy and also a main contributor to the DNA damage response. These chain types are also involved in protein stabilization and other non-degradative processes. Phospho-ubiquitin chains represent a specialized class of polyubiquitin characterized by phosphorylation at Serine 65 and play a central role in mitophagy signaling pathways. K6 Di-Ubiquitin (phosphorylated) is a dimeric chain of wild-type ubiquitin, wherein ubiquitin monomers are enzymatically linked together via an isopeptide bond between Lysine 6 and the C-terminal Glycine. The chains are then enzymatically phosphorylated at the Ser65 position.

Info

Info

Species	Human
Source	E. coli
Tag	None
Molecular Weight	17219-17299 Da (depending on degree of phosphorylation)
Quantity	25µg
Concentration	Variable
Formulation	20 mM Tris pH 7.5, 150 mM NaCl
Storage	-80°C, avoid freeze/thaw cycles

Datasheet

Investigation of phospho-ubiquitin chain specificity and selectivity
Studies on the role of phospho-ubiquitin chains in protein degradation pathways (e.g., proteasomal and autophagic degradation)
Analysis of phospho-ubiquitin-mediated signaling pathways and cellular responses
Structural studies to elucidate the architecture and dynamics of phospho-ubiquitin chains

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SI0602P: K6-Linked Di-Ubiquitin (Phosphorylated)

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