DB401: Ataxin-3

LifeSensors DB401 is a high-quality reagent for ubiquitin proteasome research, enabling advanced drug discovery and protein analysis with reliable assay support.

$167.00

SKU DB-0401-0025 Categories DUBs, MJD Family of DUBs Tags Deubiquitinating enzyme, DUB

In stock

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Applications

This enzyme cleaves K48-linked ubiquitin chains in vitro

Ataxin-3 (MJD1, SCA3) is a josephin domain-containing protein that functions as a deubiquitinase in vitro. It mediates the cleavage of long polyubiquitin chains while it has weak or no activity against chains of 4 or less ubiquitins. Ataxin-3 is the disease protein in spinocerebellar ataxia type 3 and plays a role in protein homeostasis maintenance, transcription, cytoskeleton regulation, myogenesis and degradation of misfolded chaperone substrates.

Info

Species	Human
Source	E. coli
Tag	His₆
Molecular Weight	41 kDa
Quantity	25 µg
Concentration	Variable
Formulation
Storage	-80°C, avoid freeze/thaw cycles