INTRODUCTION Proteolysis Targeting Chimeras (PROTACs) represent a promising set of drugs that target proteins without an inherent enzymatic activity for proteasomal degradation. Despite all the efforts being invested in PROTAC discovery, progress in developing drugs for clinical use is slow mainly due to the methods (Western blot, gene reporter-based methods) used to screen potential PROTAC […]
Autophagy Autophagy is a process by which eukaryotic cells degrade and recycle proteins and organelles using intracellular lysosomes. Malfunctions in autophagy have been shown to induce many diseases including cancer, neurodegeneration, diabetes, autoimmunity, and cardiovascular diseases. Autophagy and Ubiquitin Autophagy can be induced by many intra- and extra-cellular stress conditions such as endoplasmic reticulum stress, […]
Ubiquitin and Neuroscience Neurodegenerative diseases are often characterized by excessive or dysfunctional proteins and protein aggregates, which induce specific pathological conditions. The ubiquitin proteasome system and autophagy play key roles in the regulation of protein homeostasis in neurons. Accordingly, understanding enzyme dysfunction in the ubiquitin proteasome system and autophagy is critical to understanding and ultimately […]
