PROTACs & Molecular Glues
PROTACs (Proteolysis-targeting chimeric molecules) artificially hijack the components of the UPS to degrade a target protein. PROTAC drugs are hetero-bifunctional small molecules that contain two functional ligands connected via a linker; one ligand binds to a target protein and the other ligand binds to an E3 ligase.
E3 Ubiquitin Ligases Profiling & Screening
At LifeSensors, we have developed reagents and assays encompassing both traditional and non-traditional approaches for E3 ligase screening and profiling. LifeSensors’ small molecule library contains a collection of ligase-centric compounds, which can be employed as a gold standard for your ligase drug discovery efforts.
Mass Spectrometry Proteomics
Traditional methods for mass spectrometry-based proteomics, such as SILAC (stable isotope labeling with amino acids in cell culture), are insensitive, poorly reproducible, costly, and time consuming. LifeSensors’ TUBEs bind to all polyubiquitin chains with 1-10 nM affinity, overcoming major problems common to mass spectrometry proteomics.
SUMO-Tag Protein Expression & Purification
Protein expression and production of recombinant proteins routinely encounters problems, including formation of inclusion bodies, incorrect protein conformation, toxicity to the host cell, and low protein yield.
DUB Assays, Screening & Profiling
Deubiquitylases (DUBs) are enzymes that can reverse the effect of E3 ligases by removing the ubiquitin from the target proteins. Unlike most E3 ligases, DUBs have inherent catalytic activity that is easily targeted by small molecules.
Tools for PROTAC, Molecular Glues, and the Ubiquitin Proteasome System:
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Industry-leading tools for research and drug discovery
This gel based vitro ubiquitination kit has been developed to be simple and fast. E3 ligase assay is carried out....
LifeSensors MG780 Molecular Glue Evaluation Kit: Assess efficacy in protein degradation and drug discovery research.....
UC109 is a customizable, high-throughput E3 ligase assay kit for quantifying autoubiquitination and substrate ubiquitination via chemiluminescent readout.....
LifeSensors' PA950 PROTAC Assay Plate Kit: Optimized for drug discovery, this assay kit enables efficient screening of PROTACs, enhancing proteolysis-targeted....
This gel based vitro ubiquitination kit has been developed to be simple and fast. E3 ligase assay is carried out....
LifeSensors MG780 Molecular Glue Evaluation Kit: Assess efficacy in protein degradation and drug discovery research.....
UC109 is a customizable, high-throughput E3 ligase assay kit for quantifying autoubiquitination and substrate ubiquitination via chemiluminescent readout.....
LifeSensors' PA950 PROTAC Assay Plate Kit: Optimized for drug discovery, this assay kit enables efficient screening of PROTACs, enhancing proteolysis-targeted....
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With ubiquitin’s core functions in plants and animals being so similar it has long been...
The functional consequences of protein polyubiquitination are determined by the type of ubiquitin chain assembled...
While direct K-RAS inhibitors represent a major therapeutic advance, targeting this oncoprotein remains a significant...
Pan-selective Tandem Ubiquitin-Binding Entities (TUBEs) are engineered, high-affinity reagents composed of multiple ubiquitin-associated (UBA) domains...
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