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The protein encoded by UCHL1 (Ubiquitin C-Terminal Hydrolase L1) is a thiol protease belonging to the C12 family of peptidases that hydrolyze peptide bonds at the C-terminal glycine of ubiquitin. So far UCHL1 has been shown to be specifically expressed in neuronal and neuroendocrine tissues within humans. Mutations to this gene are associated with Parkinson’s disease.