Novel Approaches to PROTAC® Drug Discovery
INTRODUCTION Proteolysis Targeting Chimeras (PROTACs) represent a promising set of drugs that target proteins without an inherent enzymatic activity for proteasomal degradation. Despite all the efforts being invested in PROTAC discovery, progress in developing drugs for clinical use is slow mainly due to the methods (Western blot, gene reporter-based methods) used to screen potential PROTAC […]