Proteomics Discovery of Ubiquitylated Biomarkers for Neurodegenerative Disease
ABSTRACT Ubiquitin-Proteasome system (UPS), along with chaperone mediated-autophagy (CMA) and macroautophagy, constitutes the protein quality control system of the cell. The failure of these systems is particularly difficult to overcome in the cells that rarely grow and divide, e.g. neurons. We believe that dysfunction in UPS dysfunction plays a key causative role in diseases such […]