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Recently found to have drastic implications in Parkinson’s, researchers have shown PARIS to be a key regulating factor of neuronal death within the substantia nigra (the major site of neuronal degradation within the limbic system). In the absence of Parkin, PARIS is free of ubiquitin and carries out the role of repressing transcription leading to a downregulation of proteins responsible for energy metabolism, which in turn leads to neuronal cell death. When the E3 ligase Parkin is properly ubiquitinylating PARIS, PARIS is kept inactive/tagged for degradation and unable to ultimately cause neuronal cell death.    


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