Production of recombinant proteins routinely encounters problems, including the formation of inclusion bodies, incorrect protein conformation, toxicity to the host cell, or low protein yield. These issues are most often addressed by changing expression hosts or through fusion of the protein of interest (POI) to a carrier protein (fusion tag). Located at either the N or C- terminus of the protein of interest, fusion tags can improve protein solubility, achieve native protein folding, and increase total yield by improving expression and decreasing degradation. LifeSensors has pioneered SUMO (Small Ubiquitin Like Modifier) Fusion technology that has remarkable effect on increasing quantity and quality of recombinant proteins in prokaryotes and eukaryotes.

Expression Systems

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Protein on Demand

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Applications of the SUMO system

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