UB222: UBE2C (Ubc10)




UBE2C (also known as Ubc10) is an E2 conjugation enzyme that is involved in the ubiquitylation of target substrates, along with E1 and E3 enzymes. UBE2C interacts with the Anaphase Promoting Complex (APC) and, as a member of this complex, functions to ubiquitylate substrates and target these substrates, which include several cyclins, for degradation. As such, UBE2C plays a critical role in cell cycle progression and has recently been shown to play a key role in tumorigenesis.


Species Human
Source E. coli
Tag None
Molecular Weight 19,652.6 Da
Quantity 0.8 nmol, 3.0 nmol
Concentration 40 µM
Formulation 25 mM Tris pH 7.4, 150 mM NaCl, 10 mM DTT, 10% glycerol
Storage -80°C, avoid freeze/thaw cycles

Additional information


0.8 nmol, 3 nmol


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  • Identify cognate E2/E3 pairs
  • Characterize upregulation/downregulation of E2 enzymes
  • Build poly-ubiquitin chains
  • Characterize ubiquitin chain specificity of E2 enzymes
  • Analyze expression of E2 enzymes


  • Untagged (native) E2 conjugation enzyme