Specifications
Treatment of cells with PTC-209 leads to the selective reduction in the levels of BMI-1 protein (Kreso, van Galen et al. 2014). BMI-1 is a component of the polycomb PRC complex and interacts directly with the E3 ligase RING1A and/or RING2. The PRC complex mediates monoubiquitylation of histone H2A on Lys-119 and is involved in chromatin remodeling and repression of gene expression.
Info
| Purity | 99%; NMR consistent with structure |
| Quantity | 5 mg |
| Molecular Weight | 576.1 Da |
| Physical State | Powder |
| Solubility | 173mM in DMSO |
| CAS No. | 1217022-63-3 |
| Storage | 4°C, (-20°C Long term). The product can be shipped at room temperature. |
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