UPS Inhibitor

SI9750: DBeQ

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SKU: SI-9750 Category: Tags: ,

Specifications

DBeQ is a cell-permeable, potent, selective and reversible inhibitor of the AAA-ATPase p97 (ATPase associated with diverse cellular activities). Ki=3.2 μM. DBeQ blocks both ubiquitin-dependent and endoplasmic reticulum-associated degradation pathways, protein clearance pathways, and activates caspases -3 and -7 inducing apoptosis.

Info

Purity > 98% (TLC), NMR (Conforms)
Quantity 10 mg, 25 mg
Molecular Weight 340.4 Da
Physical State Yellow powder
Solubility DMSO (25mg/ml)
CAS No. 177355-84-9
Storage 4°C, (-20°C Long term). The product can be shipped at room temperature.

Additional information

Weight

10 mg, 25 mg

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Applications

  • To study ubiquitin-dependent and the endoplasmic reticulum-associated degradation pathway (p97 ATPase)
  • Cell biology

 

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