SI9740: Celastrol

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Specifications

Celastrol is a naturally occurring triterpenoid antioxidant compound with anti-inflammatory activity. Inhibits NFκB (IC50 = 270 nM). It induces heat shock response and cytoprotection in various cells. Celastrol inhibits 20S proteasome chymotrypsin-like activity (IC50 = 2.5 μM). Cell permeable.

Info

Purity > 98% (TLC), NMR (Conforms)
Quantity 10 mg, 50 mg
Molecular Weight 450.6 Da
Physical State Red powder
Solubility DMSO (45mg/mL); Ethanol (30mg/mL)
CAS No. 34157-83-0
Storage 4°C, (-20°C Long term). The product can be shipped at room temperature.

Additional information

Weight

10 mg, 50 mg

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Applications

  • Inhibition of NF-kappa-B-dependent pathways and inhibition of 20S proteasome chymotrypsin-like activity
  • Cell biology
  • Drug discovery
  • Benefits: cell-permeable

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