SI9720: PS-341

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Specifications

PS-341 (Pyz-Phe-boroLeu) is the active ingredient in Bortezomib (Velcade). PS-341 is a reversible, cell-permeable, potent, and selective proteasome inhibitor (Ki = 0.6 nM). It binds the catalytic site of the 26S proteasome with high affinity and specificity. Inhibits proliferation of a number of tumor cell lines (IC50 = 7 nM). Inhibits TNF synthesis and FGF-induced angiogenesis.

Info

Purity >98% (HPLC), NMR (conforms)
Quantity 5 mg, 25 mg
Molecular Weight 384.24 Da
Physical State White powder
Solubility DMSO (76 mg/mL)
CAS No. 179324-69-7
Storage 4°C, (-20°C Long term). The product can be shipped at room temperature.

Additional information

Weight

5 mg, 25 mg

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Applications

  • Inhibition of 26S proteasome
  • Cell biology
  • Benefits: cell-permeable

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