A pan-specific ubiquitin & ubiquitin-like isopeptidase inhibitor. Inhibits USP2, USP7, and SENP2 with EC50 values of 45 ± 4 μM, 37 ± 1 μM, and 9.8 ± 1.8 μM, respectively. Does not affect proteasome proteolytic activity. Induces apoptosis via a Bcl-2-dependent but apoptosome-independent mitochondrial pathway. Cell permeable.
|Purity||>98% (HPLC); NMR (Conforms)|
|Quantity||10 mg, 50 mg|
|Molecular Weight||339.9 Da|
|Physical State||Yellow Powder|
|Solubility||DMSO (8 mg/mL)|
|Storage||4°C, (-20°C Long term). Store solutions at -20°C for up to 1 month. The product can be shipped at room temperature.|