SI9649: 1,10 phenanthroline



1,10-phenanthroline (o-phenanthroline) is a chelator with a high affinity for divalent metal ions.  While not specific for DUBs, it has been shown to be a potent inhibitor of JAMM-type isopeptidases through chelation of the active site Zn2+ ion.  As such, o-phenanthroline is widely used when preparing cell lysates for the enrichment of proteins bearing K63-linked polyubiquitin chains which are especially sensitive to DUBs in the JAMM family.


Purity > 99% (TLC), NMR (conforms)
Quantity 0.5 mL DMSO solution, 100X
Molecular Weight 198.21 Da
Physical State Liquid
Solubility DMSO
CAS No. 5144-89-8
Storage -80°C. The Product can be shipped at room temperature.

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  • A critical component for protecting K63-linked polyubiquitin chains in cell lysates.