1,10-phenanthroline (o-phenanthroline) is a chelator with a high affinity for divalent metal ions. While not specific for DUBs, it has been shown to be a potent inhibitor of JAMM-type isopeptidases through chelation of the active site Zn2+ ion. As such, o-phenanthroline is widely used when preparing cell lysates for the enrichment of proteins bearing K63-linked polyubiquitin chains which are especially sensitive to DUBs in the JAMM family.
|Purity||> 99% (TLC), NMR (conforms)|
|Quantity||0.5 mL DMSO solution, 100X|
|Molecular Weight||198.21 Da|
|Storage||-80°C. The Product can be shipped at room temperature.|