UPS Inhibitor

SI9644: Spautin 1

$95.00

In stock

SKU: SI-9644-0005 Category: Tag:

Specifications

Spautin 1 inhibits USP10 and USP13 with IC50’s of 0.6 μM and 0.7 μM, respectively. These deubiquitylases target the Beclin-1 subunit and promote degradation of Vps34-PI3 kinase complexes. Its effect on autophagy is Beclin-independent. Spautin induces apoptosis of cancer cells under starvation conditions.

Info

Purity ≥98% (TLC), NMR (conforms)
Quantity 5 mg
Molecular Weight 271.3 Da
Physical State Tan colored powder
Solubility DMSO (50mg/mL)
CAS No. 126288-28-7
Storage 4°C, (-20°C long term). The product can be shipped at room temperature.

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Applications

  • USP10/USP13 inhibition
  • Inhibition of autophagy
  • Benefits: cell-permeable

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