Questions about a product, technology or experimental design? Give us a call 610-644-8845
Questions about a product, technology or experimental design? Give us a call 610-644-8845.

SI6304: K63-Linked Tetra-Ubiquitin

SKU SI-6304-0025 Categories ,
LifeSensors’ SI6304 is a K63-linked tetra-ubiquitin used in research to study ubiquitin signaling, proteomics, and drug discovery with high specificity and purity

$249.00

In stock

In stock

Polyubiquitination of target proteins through K63 has recently become the focus of intense study. The topology of this linkage type is quite different from polyubiquitin linked through lysine 48.  Modification of proteins by K63-linked polyubiquitination has been implicated in, among other cellular processes, the regulation of the DNA damage response, endosomal sorting, autophagy of misfolded/aggregated proteins, neurodegeneration, and signal transduction. Tetra-ubiquitin chains are generated from the enzymatic linkage of wild-type ubiquitin through lysine 63. The most distal ubiquitin contains an arginine substitution for the lysine at position 63, limiting chain length.

Info

Species Human
Source E. coli
Tag None
Molecular Weight 34,233.4 Da
Quantity 25µg
Concentration Variable
Formulation 20 mM Tris pH 7.5, 150 mM NaCl, 1 mM EDTA
Storage -80°C, avoid freeze/thaw cycles

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