SI4802B: K48-Linked Biotinylated Di-Ubiquitin


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SKU: SI-4802-B100 Category:


Poly-ubiquitylation of target proteins through linkage at K48, is now the most thoroughly studied of the various chain linkages, and we once considered the hallmark of this post-translational modification. It is now clear that many, if not all, poly-Ub chain topologies likely play distinct and important roles in regulating cellular processes. Nevertheless, the K48 linkage remains a critical pathway for cells to maintain homeostasis through proteolytic degradation, and as such remains very intriguing for the study of DUBs that play a role in the degradation, as well as the proteasome itself. These diubiquitin chains generated from the enzymatic linkage of wild-type ubiquitin through lysine 48. The most distal ubiquitin contains an arginine substitution for the lysine at position 48, limiting chain length.


Species Human
Source E. coli
Tag None
Molecular Weight 17,139.7 Da
Quantity 100 µg
Concentration Variable
Formulation Phosphate Buffered Saline pH 7.4
Storage -80°C, avoid freeze/thaw cycles

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  • Investigation of DUB linkage specificity.