Schematic representation of the SARS-CoV-2 structure.

CV2004: SARS-CoV-2 Spike RBD

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SKU: CV-2004-0100 Categories: ,

Specifications

Within the last two decades, SARS and MERS coronaviruses emerged as global health concerns causing severe acute respiratory syndromes. In December 2019, a novel coronavirus (SARS-CoV-2) was identified in Wuhan, Hubei province in China. The SARS-CoV-2 genome encodes several non-structural proteins including the Spike glycoprotein (S glycoprotein), which plays a crucial role in the infection of the host. The N-terminal part of the Spike protein (S1, residues 1-685) initiates the infection process by attaching the virus to host receptors (ACE2, CLEC4M/DC-SIGNR) located on the cell membrane. This interaction, which leads to the internalization of the virus into endosomes is mediated by a stretch of amino acids (residues 319-545) named the receptor binding domain (RBD). The S Protein RBD represents a valuable tool for drug discovery programs targeting SARS-CoV-2 infection.

Info

Species SARS-CoV-2
Source E.coli
Tag His6-SUMO
Molecular Weight 25.5kDa
Quantity 100 µg
Concentration Variable
Formulation
Storage -80o C. Avoid repeated freeze/thaw cycles.

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Applications

  • Detection of SARS-CoV-2 infection by ELISA
  • Purification of SARS-CoV-2 Antibodies
  • Binding Studies