LS E3 1017 is a derivative of thalidomide (Cat.No. PC-1006) and is commonly used as a precursor to PROTACs that hijack cereblon as the E3 ubiquitin ligase component. It is supplied with a carboxylic acid functional handle at a position known not to significantly affect binding to cereblon, for ready conjugation to a linker/target protein ligand.
|Quantity||5 mg, 10 mg, 25 mg|
|Molecular Weight||332.26 g/mol|
|Physical State||Lyophilized off white solid|
|Solubility||30 mg/mL in DMSO|