PC1005: Pomalidomide

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Specifications

Pomalidomide is a thalidomide derivative and a potent TNF-α inhibitor (IC50 = 13 nM). It also potently inhibits IL-2 (EC50 = 8 nM).  It binds cereblon and inhibits its ubiquitination. Pomalidomide exhibits antiproliferative effects in a Namalwa lymphoma cell line and is antiangiogenic.

Info

Purity  >95%
Quantity 1 g, 5 g
Molecular Weight 273.24 g/mol
Physical State Lyophilized pale-yellow to yellow-brown solid
Solubility 25 mg/mL in DMSO
CAS No. 19171-19-8
Storage Room Temperature

Additional information

Weight

1 g, 5 g

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Pomalidomide is a cereblon ubiquitination inhibitor. It is also a TNF-α inhibitor and antiangiogenic.