Pomalidomide is a thalidomide derivative and a potent TNF-α inhibitor (IC50 = 13 nM). It also potently inhibits IL-2 (EC50 = 8 nM). It binds cereblon and inhibits its ubiquitination. Pomalidomide exhibits antiproliferative effects in a Namalwa lymphoma cell line and is antiangiogenic.
|Quantity||1 g, 5 g|
|Molecular Weight||273.24 g/mol|
|Physical State||Lyophilized pale-yellow to yellow-brown solid|
|Solubility||25 mg/mL in DMSO|
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