VH298 is a cell permeable high-affinity inhibitor of E3 ubiquitin ligase VHL (Kd = 80-90 nM). It blocks interaction between VHL and HIF-α downstream of HIF-α hydroxylation, initiating a hypoxic response. Results in time- and concentration-dependent accumulation of hydroxylated HIF-α, and upregulates mRNA and protein levels of HIF target genes.
|Quantity||5 mg, 10 mg, 25 mg|
|Molecular Weight||523.65 g/mol|
|Physical State||Lyophilized white powder|
|Solubility||50 mg/mL in DMSO; 50 mg/mL in Ethanol|
|Storage||solutions at -20°C or -80°C; desiccated at -20°C, avoid freeze/thaw cycles|