PC1003: VH298

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SKU: PC-1003 Categories: ,

Specifications

VH298 is a cell permeable high-affinity inhibitor of E3 ubiquitin ligase VHL (Kd = 80-90 nM). It blocks interaction between VHL and HIF-α downstream of HIF-α hydroxylation, initiating a hypoxic response. Results in time- and concentration-dependent accumulation of hydroxylated HIF-α, and upregulates mRNA and protein levels of HIF target genes.

Info

Purity >98%
Quantity 5 mg, 10 mg, 25 mg
Molecular Weight 523.65 g/mol
Physical State Lyophilized white powder
Solubility 50 mg/mL in DMSO; 50 mg/mL in Ethanol
CAS No. 2097381-85-4
Storage solutions at -20°C or -80°C; desiccated at -20°C, avoid freeze/thaw cycles

Additional information

Weight

5 mg, 10 mg, 25 mg

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VH298 is a high-affinity inhibitor of VHL