DB520: USP20


In stock

SKU: DB-0520-0025 Category:


USP20 (Ubiquitin Specific Protease 20, VDU2) was identified by its homology to USP33 and binds competitively to the substrate recognition beta-domain of pVHL, a region commonly mutated in patients with pVHL disease. Furthermore, USP20 has been shown to be ubiquitinated by the pVHL E3 ligase complex in vitro and in cells. The enzyme acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2).


Species Human
Source Insect
Tag His6
Molecular Weight 105 kDa
Quantity 25 µg
Concentration Variable
Formulation 50 mM Tris pH 8.0, 150 mM NaCl, 1 mM EDTA, 5 mM DTT, 10% glycerol
Storage -80°C, avoid freeze/thaw cycles

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  • This enzyme is active in the Ub-CHOP assay.