Specifications
Xanthohumol binds to the N-terminal domain of valosin-containing protein (VCP), an essential protein for autophagosome maturation. Xanthohumol inhibits the function of VCP thereby impairing autophagosome maturation resulting in accumulation of the microtubule-associated protein 1 light chain 3-II (LC3-II). It also impairs prostate cancer cell growth and proliferation. Xanthohumol suppresses the growth of pancreatic cancer cells via down-regulation of Notch1 signaling. Xanthohumol, a prenylated chalcone from hop, inhibits COX-1 and COX-2 activity and shows chemopreventive effects.
Info
| Purity | >98% by TLC |
| Quantity | 5 mg, 25 mg |
| Molecular Weight | 354.4 g/mol |
| Physical State | Lyophilized yellow powder |
| Solubility | 35 mg/mL in DMSO or ethanol |
| CAS No. | 6754-58-1 |
| Storage | -20°C, avoid freeze/thaw cycles |
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