SENP1 is a SUMO isopeptidase that plays a critical role in the development of prostate cancer. SENP1 is overexpressed in prostate cancer samples. Overexpression of SENP1 in the prostate of mice leads to the development of prostatic intraepithelial neoplasia at an early stage. Consistent with the role of SENP1 in prostate cancer, it has demonstrated that overexpression of SENP1 enhances androgen-receptor mediated transcription. Inactivation of SENP1 in mice by retroviral insertion mutation is embryonic lethal (e12.5-e14.5) and leads to an increase in the steady state levels of SUMOylated forms of a number of proteins. Depletion of SENP1 levels in PC3 cells by RNAi leads to a decrease in cyclin D1 expression.
|Storage||-20°C; Do not aliquot|