The Ubiquitin Proteasome System (UPS) is a highly regulated pathway which controls the principal functions of almost all the cellular proteins in both the nucleus and the cytosol of eukaryotic cells. The UPS not only plays a vital role in protein degradation, but also acts as a key regulator of a wide variety of cellular processes, such as chromatin structure and function, protein trafficking, autophagy, and mitophagy. Because of the wide-reaching impact of ubiquitin and the UPS, failures in this system often contribute directly or indirectly to the pathogenesis of many diseases, including cancer, inflammation, and neurodegeneration.
At LifeSensors, our technology is focused on the ubiquitin pathway and we have developed highly innovative reagents, assays, and platforms to assist you in your research and drug discovery efforts.
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