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LifeSensors

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22
May
Lewy Body Dementia- Hiding in Plain Sight

Lewy Body Dementia- Hiding in Plain Sight

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Lewy Body Dementia- Hiding in Plain SightLewy Body Dementia (LBD) is a debilitating neurodegenerative disease, and an increasing public health concern. “In Lewy body dementia, alpha-synuclein forms in...


14
Mar
LifeSensors will Attend the 2019 Ubiquitin, Autophagy, & Disease Conference at CSHL

LifeSensors will Attend the 2019 Ubiquitin, Autophagy, & Disease Conference at CSHL

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The Cold Spring Harbor Laboratory will be hosting a conference on the Ubiquitin Proteasome System (UPS) and associated Diseases April 23rd-27th. LifeSensors will be presenting on our most recent devel...


13
Feb
LifeSensors is Proud to Sponsor the "Druggability of the Ubiquitin System" Conference in Lisbon, Portugal

LifeSensors is Proud to Sponsor the "Druggability of the Ubiquitin System" Conference in Lisbon, Portugal

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LifeSensors has spent years supporting the drug discovery efforts in Ubiquitin Proteasome System (UPS)  research. We are excited to see this growing area of research gain more attention thro...


07
Feb
Alzheimer’s Disease and PROTACs:   A New Approach to Drug Discovery

Alzheimer’s Disease and PROTACs:   A New Approach to Drug Discovery

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Alzheimer's Disease: Could Ubiquitin be Part of a Cure?by: Katelyn Roberts and Dahmane Ouazia When combing the volumes for patient stories available online I was taken aback by the profound impa...


08
Nov
Proteomics Discovery of Ubiquitylated Biomarkers for Neurodegenerative Disease

Proteomics Discovery of Ubiquitylated Biomarkers for Neurodegenerative Disease

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AbstractUbiquitin-Proteasome system (UPS), along with chaperone mediated-autophagy (CMA) and macroautophagy, constitutes the protein quality control system of the cell. The failure of these syst...


11
Dec
PROTAC Method of Action Presentation

PROTAC Method of Action Presentation

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  • 1989 Views
PROTAC Presentation-See the LifeSensors presentation on novel PROTAC assays here. Please contact us for more information on this exciting technology- bd@lifesensors.com...


14
Aug
Parkinson's Disease: Biomarkers for Early Discovery

Parkinson's Disease: Biomarkers for Early Discovery

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Parkinson's Disease: Biomarkers of Early Discovery...


26
Jul
LifeSensors to Sponsor Discovery on Target

LifeSensors to Sponsor Discovery on Target

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  • 696 Views
LifeSensors to Sponsor Discovery on TargetTo help further scientific advancement in the field of ubiquitin, LifeSensors has partnered with CHI to assist with their Discovery on Target conference this ...


10
Jul
New Developments in Ubiquitomics: Discovery of poly-ubiquitylated proteins by novel chain-selective TUBEs

New Developments in Ubiquitomics: Discovery of poly-ubiquitylated proteins by novel chain-selective TUBEs

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  • 707 Views
New Developments in Ubiquitomics: Discovery of poly-ubiquitylated proteins by novel chain-selective TUBEsLifeSensors Scientists Apurva Chaturvedi, Peter Foote, Li Liang, Dominic Vasturia, and Rajesh S...


10
Jul
Protein Profiles: CHIP

Protein Profiles: CHIP

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CHIPCHIP is an E3 that coordinates with Ataxin3 to mark misfolded chaperone proteins for UPS degradation. Deficiencies within this pathway are associated with rare disease, such as Spinocerebellar Ata...


10
Jul
Protein Profiles: Nedd4

Protein Profiles: Nedd4

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Nedd4Nedd4 is an inner membrane bound HECT E3 that promotes endocytosis of sodium channels marked for degradation at FGFR1 receptors, with K63 linked ubiquitin selectivity. Nedd4 has also been shown...


10
Jul
Protein Profiles: ITCH

Protein Profiles: ITCH

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ITCHITCH is a HECT E3, which influences immunity, the skin, and plays a role in cancer by targeting various transcription factors and growth factors.  Additionally, ITCH functions by ubiquitinyla...


10
Jul
Protein Profiles: E6-AP

Protein Profiles: E6-AP

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  • 309 Views
E6-APE6-AP (E6-associated protein) is an E3 (ubiquitin protein ligase) that is involved in the conjugation of ubiquitin to target substrates along with E1 and E2 enzymes. It is a HECT domain E3 con...


10
Jul
Protein Profiles: USP8

Protein Profiles: USP8

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USP8USP8 is associated with endosomal trafficking, it is not clear that this isopeptidase is involved in the commitment to lysosomal sorting. Additional research has shown that USP8 plays a critica...


10
Jul
Protein Profiles: USP14

Protein Profiles: USP14

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USP14USP14 is a ubiquitin specific protease that associates with the proteasome. This association with the proteasome has been shown to enhance the enzymatic activity of the proteasome. Recent stud...


10
Jul
Protein Profiles: UCHL1

Protein Profiles: UCHL1

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  • 325 Views
UCHL1The protein encoded by UCHL1 (Ubiquitin C-Terminal Hydrolase L1) is a thiol protease belonging to the C12 family of peptidases that hydrolyze peptide bonds at the C-terminal glycine of ubiquiti...


10
Jul
Protein Profiles

Protein Profiles

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  • 487 Views
Protein ProfilesMark Tingey, Dominic Vasturia, and Katie SheetsNext in its series of educational posts, LifeSensors is proud to discuss the role the proteins play in neurodegenerative diseases.  ...


18
Jun
Protein Profiles: α-Synuclein

Protein Profiles: α-Synuclein

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  • 590 Views
α-SynucleinPDB ID: 1XQ8α-Synuclein is mainly found in the brain and is present at the presynaptic terminal of neurons. Although its function in a healthy brain is currently unknown, α-Synuclein is b...


06
Jul
Protein Profiles: PINK1

Protein Profiles: PINK1

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PINK1PDB ID: 50ATPTEN induced putative kinase 1 (PINK1) is important in the role of mitophagy, once it accumulates on the outer membrane of a damaged mitochondria, it summons PARKIN to begin the pro...


18
Jun
Protein Profiles: β-Amyloid

Protein Profiles: β-Amyloid

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β-AmyloidPDB ID: 38KCAmyloid precursor proteins (APP), present in the fatty membrane of neuronal cells, undergo a series of enzymatic cleavages to create smaller proteins known as β-Amyloid. Sometim...