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LifeSensors

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05
Sep
Novel Approaches to PROTAC Drug Discovery

Novel Approaches to PROTAC Drug Discovery

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AbstractNovel Approaches to PROTAC Drug DiscoveryAuthors: Dahmane Ouazia, Haley O'Malley, Karteek KadimisettyProteolysis targeting chimeras (PROTAC) is a very promising strategy to ubiquitylate and de...


05
Sep
Ubiquitin Proteasome Dysfunction as a biomarker for Neurodegenerative Disease

Ubiquitin Proteasome Dysfunction as a biomarker for Neurodegenerative Disease

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  • 97 Views
AbstractUbiquitin Proteasome Dysfunction as a biomarker for Neurodegenerative DiseaseAuthors: Karteek Kadimisetty, Kathleen Sheets, Jess Dhillon, Dahmane OuaziaThe ubiquitin-proteasome system (UPS), c...


20
Jun
Link Between Environmental Factors and Parkinson's Disease

Link Between Environmental Factors and Parkinson's Disease

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  • 716 Views
Link Between Environmental Factors and Parkinson's DiseaseParkinson's Disease (PD) is the second most commonly diagnosed neurodegenerative disease behind Alzheimer's Disease (AD). PD occurs when dopam...


18
Jun
EMBO Ubiquitin Workshop in Cavtat from September 13-17, 2019

EMBO Ubiquitin Workshop in Cavtat from September 13-17, 2019

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  • 381 Views
LifeSensors is a proud sponsor of the EMBO Ubiquitin Workshop in Cavtat, Croatia from September 13-17, 2019! This workshop is important to the Ubiquitin community to inspire further progress and colla...


29
May
LifeSensors Attends Bio Convention 2019 in Philadelphia

LifeSensors Attends Bio Convention 2019 in Philadelphia

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LifeSensors Attends Bio Convention 2019 in Philadelphia                                  The Bio International...


07
Jun
Lewy Body Dementia - Hiding in Plain Sight

Lewy Body Dementia - Hiding in Plain Sight

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Lewy Body Dementia - Hiding in Plain SightLewy Body Dementia (LBD) is a debilitating neurodegenerative disease that is increasingly becoming a public health concern. "In Lewy body dementia, alpha-synu...


14
Mar
LifeSensors will Attend the 2019 Ubiquitin, Autophagy, & Disease Conference at CSHL

LifeSensors will Attend the 2019 Ubiquitin, Autophagy, & Disease Conference at CSHL

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The Cold Spring Harbor Laboratory will be hosting a conference on the Ubiquitin Proteasome System (UPS) and associated Diseases April 23rd-27th. LifeSensors will be presenting on our most recent devel...


13
Feb
LifeSensors is Proud to Sponsor the "Druggability of the Ubiquitin System" Conference in Lisbon, Portugal

LifeSensors is Proud to Sponsor the "Druggability of the Ubiquitin System" Conference in Lisbon, Portugal

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  • 657 Views
LifeSensors has spent years supporting the drug discovery efforts in Ubiquitin Proteasome System (UPS)  research. We are excited to see this growing area of research gain more attention thro...


07
Feb
Alzheimer’s Disease and PROTACs:   A New Approach to Drug Discovery

Alzheimer’s Disease and PROTACs:   A New Approach to Drug Discovery

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Alzheimer's Disease: Could Ubiquitin be Part of a Cure?by: Katelyn Roberts and Dahmane Ouazia When combing the volumes for patient stories available online I was taken aback by the profound impa...


08
Nov
Proteomics Discovery of Ubiquitylated Biomarkers for Neurodegenerative Disease

Proteomics Discovery of Ubiquitylated Biomarkers for Neurodegenerative Disease

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AbstractUbiquitin-Proteasome system (UPS), along with chaperone mediated-autophagy (CMA) and macroautophagy, constitutes the protein quality control system of the cell. The failure of these syst...


11
Dec
PROTAC Method of Action Presentation

PROTAC Method of Action Presentation

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PROTAC Presentation-See the LifeSensors presentation on novel PROTAC assays here. Please contact us for more information on this exciting technology- bd@lifesensors.com...


14
Aug
Parkinson's Disease: Biomarkers for Early Discovery

Parkinson's Disease: Biomarkers for Early Discovery

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Parkinson's Disease: Biomarkers of Early Discovery...


26
Jul
LifeSensors to Sponsor Discovery on Target

LifeSensors to Sponsor Discovery on Target

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LifeSensors to Sponsor Discovery on TargetTo help further scientific advancement in the field of ubiquitin, LifeSensors has partnered with CHI to assist with their Discovery on Target conference this ...


10
Jul
New Developments in Ubiquitomics: Discovery of poly-ubiquitylated proteins by novel chain-selective TUBEs

New Developments in Ubiquitomics: Discovery of poly-ubiquitylated proteins by novel chain-selective TUBEs

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New Developments in Ubiquitomics: Discovery of poly-ubiquitylated proteins by novel chain-selective TUBEsLifeSensors Scientists Apurva Chaturvedi, Peter Foote, Li Liang, Dominic Vasturia, and Rajesh S...


10
Jul
Protein Profiles: CHIP

Protein Profiles: CHIP

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CHIPCHIP is an E3 that coordinates with Ataxin3 to mark misfolded chaperone proteins for UPS degradation. Deficiencies within this pathway are associated with rare disease, such as Spinocerebellar Ata...


10
Jul
Protein Profiles: Nedd4

Protein Profiles: Nedd4

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Nedd4Nedd4 is an inner membrane bound HECT E3 that promotes endocytosis of sodium channels marked for degradation at FGFR1 receptors, with K63 linked ubiquitin selectivity. Nedd4 has also been shown...


10
Jul
Protein Profiles: ITCH

Protein Profiles: ITCH

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ITCHITCH is a HECT E3, which influences immunity, the skin, and plays a role in cancer by targeting various transcription factors and growth factors.  Additionally, ITCH functions by ubiquitinyla...


10
Jul
Protein Profiles: E6-AP

Protein Profiles: E6-AP

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  • 495 Views
E6-APE6-AP (E6-associated protein) is an E3 (ubiquitin protein ligase) that is involved in the conjugation of ubiquitin to target substrates along with E1 and E2 enzymes. It is a HECT domain E3 con...


10
Jul
Protein Profiles: USP8

Protein Profiles: USP8

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  • 484 Views
USP8USP8 is associated with endosomal trafficking, it is not clear that this isopeptidase is involved in the commitment to lysosomal sorting. Additional research has shown that USP8 plays a critica...


10
Jul
Protein Profiles: USP14

Protein Profiles: USP14

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  • 455 Views
USP14USP14 is a ubiquitin specific protease that associates with the proteasome. This association with the proteasome has been shown to enhance the enzymatic activity of the proteasome. Recent stud...