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LifeSensors

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08
Nov
Proteomics Discovery of Ubiquitylated Biomarkers for Neurodegenerative Disease

Proteomics Discovery of Ubiquitylated Biomarkers for Neurodegenerative Disease

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AbstractUbiquitin-Proteasome system (UPS), along with chaperone mediated-autophagy (CMA) and macroautophagy, constitutes the protein quality control system of the cell. The failure of these syst...


06
Nov
PROTAC Method of Action Presentation

PROTAC Method of Action Presentation

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  • 407 Views
PROTAC Presentation-See the LifeSensors presentation on novel PROTAC assays here. Please contact us for more information on this exciting technology- bd@lifesensors.com...


14
Aug
Parkinson's Disease: Biomarkers for Early Discovery

Parkinson's Disease: Biomarkers for Early Discovery

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Parkinson's Disease: Biomarkers of Early Discovery...


26
Jul
LifeSensors to Sponsor Discovery on Target

LifeSensors to Sponsor Discovery on Target

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  • 285 Views
LifeSensors to Sponsor Discovery on TargetTo help further scientific advancement in the field of ubiquitin, LifeSensors has partnered with CHI to assist with their Discovery on Target conference this ...


10
Jul
New Developments in Ubiquitomics: Discovery of poly-ubiquitylated proteins by novel chain-selective TUBEs

New Developments in Ubiquitomics: Discovery of poly-ubiquitylated proteins by novel chain-selective TUBEs

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  • 377 Views
New Developments in Ubiquitomics: Discovery of poly-ubiquitylated proteins by novel chain-selective TUBEsLifeSensors Scientists Apurva Chaturvedi, Peter Foote, Li Liang, Dominic Vasturia, and Rajesh S...


10
Jul
Protein Profiles: CHIP

Protein Profiles: CHIP

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CHIPCHIP is an E3 that coordinates with Ataxin3 to mark misfolded chaperone proteins for UPS degradation. Deficiencies within this pathway are associated with rare disease, such as Spinocerebellar Ata...


10
Jul
Protein Profiles: Nedd4

Protein Profiles: Nedd4

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Nedd4Nedd4 is an inner membrane bound HECT E3 that promotes endocytosis of sodium channels marked for degradation at FGFR1 receptors, with K63 linked ubiquitin selectivity. Nedd4 has also been shown...


10
Jul
Protein Profiles: ITCH

Protein Profiles: ITCH

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ITCHITCH is a HECT E3, which influences immunity, the skin, and plays a role in cancer by targeting various transcription factors and growth factors.  Additionally, ITCH functions by ubiquitinyla...


10
Jul
Protein Profiles: E6-AP

Protein Profiles: E6-AP

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  • 114 Views
E6-APE6-AP (E6-associated protein) is an E3 (ubiquitin protein ligase) that is involved in the conjugation of ubiquitin to target substrates along with E1 and E2 enzymes. It is a HECT domain E3 con...


10
Jul
Protein Profiles: USP8

Protein Profiles: USP8

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  • 106 Views
USP8USP8 is associated with endosomal trafficking, it is not clear that this isopeptidase is involved in the commitment to lysosomal sorting. Additional research has shown that USP8 plays a critica...


10
Jul
Protein Profiles: USP14

Protein Profiles: USP14

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USP14USP14 is a ubiquitin specific protease that associates with the proteasome. This association with the proteasome has been shown to enhance the enzymatic activity of the proteasome. Recent stud...


10
Jul
Protein Profiles: UCHL1

Protein Profiles: UCHL1

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  • 128 Views
UCHL1The protein encoded by UCHL1 (Ubiquitin C-Terminal Hydrolase L1) is a thiol protease belonging to the C12 family of peptidases that hydrolyze peptide bonds at the C-terminal glycine of ubiquiti...


10
Jul
Protein Profiles

Protein Profiles

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  • 265 Views
Protein ProfilesMark Tingey, Dominic Vasturia, and Katie SheetsNext in its series of educational posts, LifeSensors is proud to discuss the role the proteins play in neurodegenerative diseases.  ...


18
Jun
Protein Profiles: α-Synuclein

Protein Profiles: α-Synuclein

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  • 255 Views
α-SynucleinPDB ID: 1XQ8α-Synuclein is mainly found in the brain and is present at the presynaptic terminal of neurons. Although its function in a healthy brain is currently unknown, α-Synuclein is b...


06
Jul
Protein Profiles: PINK1

Protein Profiles: PINK1

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  • 172 Views
PINK1PDB ID: 50ATPTEN induced putative kinase 1 (PINK1) is important in the role of mitophagy, once it accumulates on the outer membrane of a damaged mitochondria, it summons PARKIN to begin the pro...


18
Jun
Protein Profiles: β-Amyloid

Protein Profiles: β-Amyloid

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  • 314 Views
β-AmyloidPDB ID: 38KCAmyloid precursor proteins (APP), present in the fatty membrane of neuronal cells, undergo a series of enzymatic cleavages to create smaller proteins known as β-Amyloid. Sometim...


19
Jun
Protein Profiles: Paris (ZNF746)

Protein Profiles: Paris (ZNF746)

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Source: https://doi.org/10.1016/j.cell.2011.02.010PARIS (ZNF746)Recently found to have drastic implications in Parkinson’s, researchers have shown PARIS to be a key regulating factor of neuronal...


06
Jul
Protein Profiles: Parkin

Protein Profiles: Parkin

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ParkinPDB ID: 5C1ZParkin is an E3 ligase, which ubiquitinylates proteins for degradation within neurons, and is primarily associated with mitophagy. By tagging damaged proteins with ubiquitin, the n...


18
Jun
Protein Profiles: Tau Proteins

Protein Profiles: Tau Proteins

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  • 141 Views
Tau ProteinsPDB ID: 5D2VWithin healthy neurons, tau proteins are responsible for stabilizing microtubules within the cell. Unfortunately, in instances associated with neurodegenerative disease these...


31
May
LifeSensors to Attend the 2018 BIO International Convention

LifeSensors to Attend the 2018 BIO International Convention

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LifeSensors is a leader in Ubiquitin Proteasome System (UPS) drug discovery technologies and SUMO Platform for Difficult to Express Proteins. We are pleased to inform you that members of our team will...