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SI9649- 1,10 phenanthroline, 0.5ml

$105.00
  • Product Code: SI9649- 1,10 phenanthroline, -.5ml
  • Availability: 2-3 Days

1,10-phenanthroline (o-phenanthroline) is a chelator with high affinity for divalent metal ions.  While not specific for DUBs, it has been shown to be a potent inhibitor of JAMM-type isopeptidases through chelation of the active site Zn2+ ion.  As such, o-phenanthroline is widely used when preparing cell lysates for enrichment of proteins bearing K63-linked polyubiquitin chains which are especially sensitive to DUBs in the JAMM family.

Info
Purity   > 99%
Molecular Weight   198.21 Da
State   0.5 M DMSO solution, 100X
Storage   -80°C Product can be shipped at room temperature.



Applications
  • A critical component for protecting K63-linked polyubiquitin chains in cell lysates.


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