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LifeSensors

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E1-E2-E3 inhibitors



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PYR-41 is a cell permeable, irreversible inhibitor of ubiquitin activating enzyme E1 with little or ..
$175.00

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PYR-41 is a cell permeable, irreversible inhibitor of ubiquitin activating enzyme E1 with little or ..
$295.00

Available Options

PYR-41 is a cell permeable, irreversible inhibitor of ubiquitin activating enzyme E1 with little or ..
$545.00

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An oral, phase 1 hdm2 antagonist.  Binds the RING domain of MDM2 and inhibits survival in cancer cel..
$195.00

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Thalidomide binds to the E3 ubiquitin ligase complex formed between cereblon (CRBN), damaged DNA bin..
$95.00

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Thalidomide binds to the E3 ubiquitin ligase complex formed between cereblon (CRBN), damaged DNA bin..
$165.00

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Inhibits MDMX resulting in increased p53 activity and DNA damage.Info Chemical Formula  ..
$245.00

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Containing the active ingredient of MLN4924 which acts as a substrate-assisted inhibitor of the NEDD..
$180.00

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RITA binds full-length p53 and blocks p53-hdm2 interaction and p53 ubiquitination. PubChem ID: ..
$245.00

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Inhibits the ubiquitin ligase anaphase-promoting complex/cyclosome (APC/C) by inhibiting binding and..
$155.00

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Inhibits the cullin-RING ubiquitin E3 ligase SCF-Skp2. Selectively inhibits Skp2-mediated p27 degrad..
$125.00

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A cell-permeable, non-peptide inhibitor of MDM2-p53 interactions (Ki=120nM).  Treatment of cancer ce..
$195.00

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Treatment of cells with PTC-209 leads to the selective reduction in the levels of BMI-1 protein (Kre..
$175.00

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Inhibits the p53-MDM2 interaction (20 µM). Inhibits U2Os cell growth (EC50=10µM). Has also been show..
$155.00

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Tenovin 1 inhibits the deacetylase activity of SirT1 and SirT2. One of the substrates for SirT1 is p..
$115.00

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Cis-imidazoline analog that inhibits the interaction between p53 and its negative regulator MDM2 (IC..
$195.00

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Small Molecule Enhancer of Rapamycin 3 (SMER3) is a specific inhibitor of the ubiquitin E3 ligase SC..
$195.00

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Small Molecule Enhancer of Rapamycin 3 (SMER3) is a specific inhibitor of the ubiquitin E3 ligase SC..
$640.00

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Small Molecule Enhancer of Rapamycin 3 (SMER3) is a specific inhibitor of the ubiquitin E3 ligase SC..
$975.00

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A potent inhibitor of histone H2A ubiquitylation. Inhibits RNF2 and Ring1A, both of which are found ..
$95.00
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