The functional consequences of protein polyubiquitination are determined by the type of ubiquitin chain assembled on the substrate. Among the eight known linkage types, lysine 48 (K48)-linked chains target proteins for proteasomal degradation, whereas lysine 63 (K63)-linked chains primarily regulate intracellular signaling, trafficking, autophagy, mitophagy, and mitochondrial biogenesis. Therapeutic strategies that exploit the ubiquitin–proteasome system […]
Pan-selective Tandem Ubiquitin-Binding Entities (TUBEs) are engineered, high-affinity reagents composed of multiple ubiquitin-associated (UBA) domains that bind polyubiquitin chains with very high affinity. Their design enables pan-specific capture of all ubiquitin chain linkage types (K6, K11, K27, K29, K33, K48, K63, and M1)—overcoming the inherent bias of antibody-based methods like DiGly enrichment. Critically, TUBEs preserve […]
LifeSensors is pleased to bring attention to some of our academic colleagues who have used our products in the past to make discoveries and publications in the Ubiquitin Proteasome System field and further beyond. From E1s to SUMO expression, phosphorylation to deubiquitinases, we’re happy to have been a part of scientific discovery, and look forward […]
Different lysines on ubiquitin are involved in forming different ubiquitin chains, with K48-linked chains primarily signaling for proteasomal degradation, while other linkages, such as K63-linked chains, and single ubiquitin molecules (monoubiquitination) act as non-degradative signals for processes like DNA repair, signal transduction, and trafficking. Due to the diverse signaling and the multiple different lysines (K6, […]
The PA950 and PA770 are important assays for studying ubiquitination due to an E3 ligase or PROTAC, and the launch of the MG780 kit also extends this functionality to Molecular glues, opening up new options to test and verify functionality of compounds prior to later stage development, allowing ubiquitination to be confirmed which minimizes turnaround […]
By: Derrick Padykula Ubiquitination, a ubiquitous cellular process, involves attaching ubiquitin to target proteins, influencing crucial cellular functions such as degradation, cell signaling, apoptosis, protein processing, immune response, and DNA repair. The specific ubiquitin chain type, whether M1, K6, K11, K27, K29, K33, K48, or K63-linked, dictates the downstream processing of the target protein. Delving […]
MALVERN, Pa., October 26, 2023 — LifeSensors, Inc., a leading innovator in protein degradation technologies, has been invited to speak at the 6th Annual Targeted Protein Degradation Summit 2023 in Boston, Massachusetts. The event will take place from October 30-November 2 at Westin Copley Place, Boston. LifeSensors will be exhibiting, and Dr. Karteek Kadimisetty will […]
MALVERN, Pa., SEP 21, 2023 — LifeSensors Inc., a Biotech and Drug Discovery Company focused on PROTAC, molecular glue drug discovery and neurodegeneration diagnostics has been invited to speak at the 21st annual Discovery on Target 2023. Dr. Karteek Kadimisetty, LifeSensors’ Director of Research and Development will be presenting new information, and answering questions regarding PROTACs, […]
LifeSensors has spent years supporting the drug discovery efforts in Ubiquitin Proteasome System (UPS) research. We are excited to see this growing area of research gain more attention through conferences like this. We believe PROTACs and other modulators of the UPS will make profound impacts in the clinic, on a variety of “undruggable” targets. LifeSensors […]
LifeSensors is a leader in Ubiquitin Proteasome System (UPS) drug discovery technologies and SUMO Platform for Difficult to Express Proteins. We are pleased to inform you that members of our team will be at Bio International Convention and Biopartnering on June 4-7th 2018 in Boston. BIO International brings biotechnology and pharmaceutical companies together to partner […]
