TAU PROTEINS PDB ID: 5D2V Within healthy neurons, tau proteins are responsible for stabilizing microtubules within the cell. Unfortunately, in instances associated with neurodegenerative disease these proteins are found to…
PARKIN PDB ID: 5C1Z Parkin is an E3 ligase, which ubiquitinylates proteins for degradation within neurons, and is primarily associated with mitophagy. By tagging damaged proteins with ubiquitin, the neuron…
PARIS (ZNF746) Recently found to have drastic implications in Parkinson’s, researchers have shown PARIS to be a key regulating factor of neuronal death within the substantia nigra (the major site…
Β-AMYLOID PDB ID: 38KC Amyloid precursor proteins (APP), present in the fatty membrane of neuronal cells, undergo a series of enzymatic cleavages to create smaller proteins known as β-Amyloid. Sometimes,…
PINK1 PDB ID: 50AT PTEN induced putative kinase 1 (PINK1) is important in the role of mitophagy, once it accumulates on the outer membrane of a damaged mitochondria, it summons…
Α-SYNUCLEIN PDB ID: 1XQ8 α-Synuclein is mainly found in the brain and is present at the presynaptic terminal of neurons. Although its function in a healthy brain is currently unknown,…
UBIQUITIN: HOPE FOR THE FUTURE OF ALZHEIMER’S RESEARCH by: Mark Tingey and Peter Foote Uncle Walt stared at us, not recognizing us or remembering our names. His eyes, which were…