Ubiquitin and Neuroscience Neurodegenerative diseases are often characterized by excessive or dysfunctional proteins and protein aggregates, which induce specific pathological conditions. The ubiquitin proteasome system and autophagy play key roles…
Lewy Body Dementia (LBD) is a debilitating neurodegenerative disease that is increasingly becoming a public health concern. “In Lewy body dementia, alpha-synuclein forms into clumps inside neurons, starting in areas…
By: Mark Tingey, Katelyn Roberts, and Meredith Paterson Parkinson’s disease is often referred to as a silent disease. It often begins in very innocuous ways, small ticks and behaviors that…
UCHL1 The protein encoded by UCHL1 (Ubiquitin C-Terminal Hydrolase L1) is a thiol protease belonging to the C12 family of peptidases that hydrolyze peptide bonds at the C-terminal glycine of…
USP14 USP14 is a ubiquitin specific protease that associates with the proteasome. This association with the proteasome has been shown to enhance the enzymatic activity of the proteasome. Recent studies…
USP8 USP8 is associated with endosomal trafficking, it is not clear that this isopeptidase is involved in the commitment to lysosomal sorting. Additional research has shown that USP8 plays a…
E6-AP E6-AP (E6-associated protein) is an E3 (ubiquitin protein ligase) that is involved in the conjugation of ubiquitin to target substrates along with E1 and E2 enzymes. It is a…
ITCH ITCH is a HECT E3, which influences immunity, the skin, and plays a role in cancer by targeting various transcription factors and growth factors. Additionally, ITCH functions by ubiquitinylating…
NEDD4 Nedd4 is an inner membrane bound HECT E3 that promotes endocytosis of sodium channels marked for degradation at FGFR1 receptors, with K63 linked ubiquitin selectivity. Nedd4 has also been…
CHIP CHIP is an E3 that coordinates with Ataxin3 to mark misfolded chaperone proteins for UPS degradation. Deficiencies within this pathway are associated with rare disease, such as Spinocerebellar Ataxia,…