UCHL1 (PGP9.5) is a 25 kDa protein; it is highly specific to neurons and to cells of the diffuse neuroendocrine system and their tumors. It comprises >1% of total brain protein but is almost absent from other tissues. It has been implicated both in Parkinson's disease and in lung cancer.
|Molecular Weight||25 kDa|
|Storage||Store at -80°C, avoiding repeated freeze-thaw cycles.|
|Expression Host||E. coli|
|Alternative Names||Neuron cytoplasmic protein 9.5, PARK5, PGP9.5, PGP 9.5, Ubiquitin carboxyl-terminal hydrolase isozyme L1, Ubiquitin thioesterase L1, UCH-L1|
|Suggested Substrate||Ubiquitin-Rhodamine (Cat. # SI230)|
- This enzyme cleaves Ub-AMC.