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LifeSensors

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UB304-25µg E6AP

$180.00
  • Product Code: UB304-25µg E6AP
  • Availability: In Stock
Tags: E3 ligase

E6-AP (E6-associated protein) is an E3 (ubiquitin protein ligase) that is involved in the conjugation of ubiquitin to target substrates along with E1 and E2 enzymes. It is a HECT domain E3 containing an active site cysteine which accepts a charged ubiquitin from the ubiquitin-E2 thiolester complex. E6-AP has been linked to a neurodevelopmental disorder, Angelman syndrome. In addition the oncoprotein E6 of human papillomaviruses (HPV) utilizes E6-AP to target numerous cellular proteins for degradation including the tumor suppressor protein p53.

Info
Amount   25 µg
State   Liquid
Molecular Weight   101 kDa
Source   Human Recombinant
Fusion Tag   None
Storage   Store at -80°C, avoiding repeated freeze-thaw cycles.
Alternative Names   Ubiquitin-protein ligase E3A, UBE3A
Accession Number   NP_000453



Applications
  • Typical enzyme concentration of 100 nM – 5 µM is used for in vitro conjugation, depending on conditions.


Documents

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