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UB304-25µg E6AP

  • Product Code: UB304-25µg E6AP
  • Availability: In Stock
Tags: E3 ligase

E6-AP (E6-associated protein) is an E3 (ubiquitin protein ligase) that is involved in the conjugation of ubiquitin to target substrates along with E1 and E2 enzymes. It is a HECT domain E3 containing an active site cysteine which accepts a charged ubiquitin from the ubiquitin-E2 thiolester complex. E6-AP has been linked to a neurodevelopmental disorder, Angelman syndrome. In addition the oncoprotein E6 of human papillomaviruses (HPV) utilizes E6-AP to target numerous cellular proteins for degradation including the tumor suppressor protein p53.

Amount   25 µg
State   Liquid
Molecular Weight   101 kDa
Source   Human Recombinant
Fusion Tag   None
Storage   Store at -80°C, avoiding repeated freeze-thaw cycles.
Alternative Names   Ubiquitin-protein ligase E3A, UBE3A
Accession Number   NP_000453

  • Typical enzyme concentration of 100 nM – 5 µM is used for in vitro conjugation, depending on conditions.


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